Archive for the ‘bio-identical hormones’ Tag

Bioidentical Hormones, Bio-identical Hormones, Bioidentical Hormone Therapy, Bioidenticals, Natural Hormone Therapy for Menopause   Leave a comment

Natural Hormone Replacement Therapy (NHRT): If you are currently on or considering the use of Hormone Replacement Therapy (HRT) and you think individualized, natural HRT makes more sense than a “one-size-fits-all” approach, then you may want to look into naturally compounded, bio identical, plant-derived Hormone Replacement Therapy. Compounding is preparing medicines tailored to patients’ individual needs. Compounding is the preparation, mixing, assembling, packaging, or labeling of a drug as the result of a practitioner’s Prescription Drug Order based on the pharmacist-patient-prescriber relationship. Compounding offers patients their choice of drug, strength, dosage form, excipients, or lack of and can be decided on a case-by-case basis. This process allows for medical treatments that otherwise might not be possible.

With an individualized approach to hormone therapy, you can know exactly what your hormone levels are, compare the benefits vs. risks of all possible therapies, and choose the ideal replacement protocol to bring your hormones back to their proper balance. If your doctor is willing to prescribe conventional HRT, s/he should be more than willing to prescribe naturally compounded HRT.

Estradiol, the principal estrogen found in a woman’s body during the reproductive years, is produced by the ovaries. Estradiol is very effective for the symptomatic relief of hot flashes, genitourinary symptoms, osteoporosis prophylaxis, psychological well-being and reduction of coronary artery disease.

Because it is much more potent than estriol, it can be more effective for symptomatic relief than estriol. When Estradiol is replaced using a parenteral (sublingual, percutaneous, or transdermal) route, it is not subject to first pass metabolism by the liver, and therefore does no produce high levels of estrone. Using these routes of administration a woman can mimic the physiologic release of estradiol from the ovaries, thus receiving natural hormone replacement.

ESTRIOL (E3)

Estriol is the weakest of the three major estrogens. In fact it is 1000 times weaker in its effect on breast tissue. Estriol is the estrogen that is made in large quantities during pregnancy and has potential protective properties against the production of cancerous cells.

An important article in the 1966 Journal of the American Medical Association by H.M. Lemmon, M.D., reported a study showing that higher levels of estriol in the body correlate with remission of breast cancer. Dr. Lemmon demonstrated that women with breast cancer had reduced urinary excretion of estriol. He also observed that women without breast cancer have naturally higher estriol levels, compared with estrone and estradiol levels, than women with breast cancer. Vegetarian and Asian women have high levels of estriol, and these women are at much lower risk of breast cancer than are other women. Estriol’s anticancer effect is probably related to its anti-estrone properties-it blocks the stimulatory effect of estrone by occupying the estrogen receptor sites on the breast cells.

Estriol is the estrogen most beneficial to the vagina, cervix and vulva. In cases of vaginal dryness and atrophy, which predisposes a woman to vaginitis and cystitis, topical estriol is the most effective and safest estrogen to use. Because of this estriol is better than estradiol for the treatment of urinary tract infections.

None of the American drug products contain Estriol, so it is not available in most drug stores, although it has been used widely in Europe for over fifty years. Because estriol cannot be patented it does not hold much interest for the pharmaceutical industry. Its availability through compounding has caused its use to grow rapidly throughout the country.

ESTRONE (E1)

Estrone is the estrogen most commonly found in increased amounts in post menopausal women. The body derives it from the hormones that are stored in body fat. Estrone does the same work that estradiol does, but it is considered weaker in its effects.

BI-EST

Biest is a combination of two estrogens: estriol and estradiol. It is most commonly found in a ratio of 80:20, estriol to estradiol. This combination allows for all of the protection of estriol while providing the cardiovascular and osteoporosis benefits along with the vasomotor symptom relief of estradiol.

TRI-EST

Triest is a combination of three estrogens: estriol, estradiol and estrone. It is most commonly found in a ratio of 80:10:10, estriol, estradiol, and estrone. This combination is very popular and contains all of the three major circulating estrogens. It is slightly weaker in its effect when compared to biest. However, this can be compensated for by increasing the strength or by slightly changing the ratios.

PROGESTERONE

Progesterone is produced by the ovaries and the adrenal glands in women and, in smaller amounts, in the testes and the adrenal glands in men. One of its most important functions is in the female reproductive cycle. Progesterone prepares the lining of the uterus for implantation of a fertilized egg, then helps to maintain it during pregnancy. If pregnancy does not occur it signals the uterus to shed this lining.

Progesterone also plays an important role in brain function and is often called the “feel good hormone” because of its mood enhancing and antidepressant effects. Optimum levels of progesterone can mean feelings of calm and well being, while low levels of progesterone can mean feelings of anxiety, irritability and even anger. Current research shows that progesterone may pay a role in the maintenance of the nervous system, the sense of touch, and motor function.

PREGNENOLONE

Pregnenolone is a superhormone that is key to keeping our brains functioning at peak capacity. Some scientists believe it is the most potent memory enhancer of all time. Perhaps what is even more amazing are the studies that demonstrate pregnenolone enhances our ability to perform on the job while heightening feelings of well-being. In other words, this superhormone appears to make us not only smarter but also happier.

Like the other steroid hormones pregnenolone is synthesized from cholesterol. In a complex series o steps, cholesterol is broken down into different steroid hormones as the body needs them. It is first synthesized into pregnenolone and used by the body in that form. What is not utilized undergoes a chemical change that “repackages” it into DHEA. DHEA in turns used by the body as DHEA and is also broken down into estrogen and testosterone. This chain of hormones is known as the “steroid pathway.” Because pregnenolone gives birth to the other hormones, it is sometimes referred to as the “parent hormone.”

Pregnenolone was studied extensively in the 1940s. It was shown to be beneficial in elevating mood, improving concentration, fighting mental fatigue, improving memory and relieving severe joint pain and fatigue in arthritis. Pregnenolone has vast therapeutic potential and is currently undergoing further studies in these areas.

DHEA

Short for Dehydroepiandrosterone, DHEA is a steroid hormone distinguished from others by its unique chemical structure. DHEA is produced by the adrenal glands (located just above the kidneys) as well as by the brain and the skin, and is the most abundant steroid in the human body.

As newborns, we have an extremely high level of DHEA, but within a few days after birth, our DHEA level drops to nearly zero. Then between the ages of six and eight, we experience the even called “adrenarche” in which our adrenal glands begin to stir and gear up for puberty. At the same time our DHEA level begins to rise steadily and continues to rise until it peaks at around age twenty-five to thirty. From that point on in declines at a rate of about 2 percent a year, and we begin to feel the result of this decline in our mid-forties. By eighty our DHEA level is only fifteen percent of what it was when we were twenty-five. This drop in DHEA levels correlates dramatically with the signs and “symptoms” associated with aging.

DHEA is currently the focus of some of the most exciting medical research of this century. Researchers at distinguished medical centers all over the country are studying the properties and promise of DHEA. It is proving to be a potent protector against cancer. It protects against heart disease by lowering blood cholesterol and preventing blood clots. Studies also demonstrate that DHEA improves memory, strengthens the immune system, prevents bone loss, and may even protect us from diabetes and autoimmune disease. It has been shown to fight fatigue and depression; it enhances feelings of well-being and increases strength. DHEA alleviates symptoms of menopause, reduces body fat, and is even known to enhance libido.

Because DHEA is showing such tremendous promise in so many areas, and because of the limited amount of space provided here, we recommend further reading on the superstar of superhormones. An excellent resource for more information is the book “The Superhormone Promise” by W. Regelson, M.D., and Carol Colman.

TESTOSTERONE

Usually considered a male hormone or androgen, women also produce testosterone although in much smaller amounts than men do. Testosterone works differently in the bodies of men and women, but it plays a very important role in the overall health and well-being of both sexes. Often called the “hormone of desire” because of its powerful effect on libido, testosterone is also important in building strong muscles, bones, and ligaments as well as increasing energy and easing depression. Low levels of testosterone have been known to cause fatigue, irritability, depression, aches and pain in the joints, thin and dry skin, osteoporosis, weight loss, and the loss of muscle development.

As with all of the hormones, testosterone must be dosed properly to be effective without causing unwanted side effects. The dose in women is generally one-tenth that used in men. Because testosterone is not effective when it is taken orally it is usually prescribed as a topical gel, cream or as a sublingual tablet. Although testosterone was discovered more than sixty years ago, only very recently have we begun to fully understand and appreciate the power of testosterone.

HUMAN GROWTH HORMONE – HGH

HGH is one of many endocrine hormones, like estrogen, progesterone, testosterone, melatonin and DHEA, that all decline in production with age. While many of these hormones can be replaced to deter some of the effects of aging, HGH reaches far beyond the scope of any of these hormones. Not only does it prevent biological aging, but it acts to significantly reverse a broad range of the signs and symptoms associated with the aging process.

The decline of growth hormone with age is directly associated with many of the symptoms of aging, including wrinkling, gray hair, hair loss, decreased energy and sexual function, loss of muscle and increased body fat, cardiovascular disease, osteoporosis, and overall lower life expectancy.

The good news is that there is now clinical evidence which demonstrates that by replacing growth hormone we can dramatically reverse all of these symptoms. Although this may appear to be too good to be true, the more closely the scientific evidence is examined the more clear it becomes that everything that we associate with aging may be due totally or in part to the decline of HGH levels in our bodies.

Until recently, the only way to increase HGH levels in the body, was to use injectable HGH. These injections are very effective, although they are costly and difficult to use. Now, there are natural substances that have been well documented to increase growth hormone by stimulating the bodyís own production of HGH. According to researchers, these cutting edge natural secretagogues may have the ability to more closely mimic the bodyís youthful GH secretion patterns.

These natural substances which stimulate the body’s own production of HGH are known as secretagogues. They can be introduced into the body in two ways: orally or transdermally (topically applied to the skin).

The oral secretagogues are very popular and have shown to be very effective. They include such products as Pro-HGH®, Rejuvamin®, Rejuvamax® and Medi-Tropin®. Though effective, all of these except Medi-Tropin® are available without a prescription. Achieving consistent results with the oral products can be difficult due to changes in absorption from the stomach and the necessity for the stomach to be empty for four hours prior to use.

Trans-D Tropin ®

Trans-D Tropin ®, a transdermal product that is now available by prescription only, provides a very efficient delivery system and an ease of administration that leads to better patient compliance and consistent results. Trans-D Tropin ® is a natural complex which mimics growth hormone releasing hormone(GHRH). The transdermal delivery system allows frequent dosing, up to four times daily, which more closely resembles the body’s own natural response. Imitating this natural response results in an effective and superior release of the body’s own growth hormone.

Saliva Test for Hormones

Adequate levels and an appropriate balance of the steroid hormones (estradiol, progesterone, testosterone, DHEA, cortisol) are necessary for maintaining optimal health and well being in both females and males. This family of steroid hormones supports a wide range of essential physiological functions, including blood lipid balance, bone mineral density, fertility, sexuality, a general sense of well being, as well as certain aspects of brain functioning. The saliva test measures levels of specific hormones that are produced in the body, consumed as foods, dietary supplements or medication. Saliva yields a direct measure of “free hormone ” level and is comparable to that measured by blood. Also, timing of the test can be precisely controlled and levels can be determined at optimum times. Saliva testing provides a means to establish whether or not your hormone levels are within the expected normal range and it is simple and non-invasive. It is appropriate to monitor and titrate doses to minimize side effects and risks without compromising the benefits of replacement therapy.

 

Estradiol

Estriol

Progesterone

Testosterone

DHEA

Cortisol

Melatonin

Total Estrogens

Total Progestins

PyriLinks-D (urine sample)

* must be ordered by a physician

Medical insurance may pay for testing

The 34 Symptoms of Menopause – what they are and how to treat them   34 comments

MaryO’Note: Links are removed from this list


There’s been a list of the “34 signs of menopause” circulating for years. The list originated with Judy Bayliss’ wonderful newsgroup, The Menopaus Listserv (That’s Menopaus without the “e” at the end).

I’ve taken the liberty of adding my own Notes to the original list. You’ll find hundreds of articles pertaining to menopause symptoms, treatments and menopause / midlife-related health and emotional issues including articles on midlife relationships, weight and fitness issues, intimacy, psychological problems associated with menopause in Power Surge’s, “Educate Your Body” extensive library.

I suggest you begin with the comprehensive article explaining what menopause is: in “An Introduction To Menopause: Signs, Symptoms and Treatments”

You’ll find remedies for most of these symptoms on the Recommendations page.

Here is the list of: “The 34 Signs of Menopause:”

1. Hot flashes, flushes, night sweats and/or cold flashes, clammy feeling (related to increased activity in the autonomic / sympathetic nervous system). Without becoming too, technical, messages are sent to the hypothalmus because of declining estrogen production via neurons which result in vasodilation — widening of the lumen of blood vessels (lumen being the cavity of a tubular organ, i.e., the lumen of a blood vessel,) which, in turn, causes flushing or hot flashes. Tips for treating/minimizing (and even avoiding) hot flashes: Power Surge’s Menopause Survival Tips. Also, read the Power Surges (hot flashes) Forum

2. Bouts of rapid heartbeat (related to increased activity in the autonomic / sympathetic nervous system)

Note: Along with rapid heartbeat (palpitations), women can experience skipped heartbeats, irregular heartbeats. These are generally normal vasomotor responses experienced during menopause – usually due to fluctuating hormone levels. However, if these problems continue, it’s always a good idea to be checked by your health care practitioner. An echocardiogram is a common procedure to tell the doctor what he needs to know about your heart. If your health care practitioner doesn’t suggest it, ASK FOR IT! Read the Palpitations, Heart Issues, Hypertension Forum

3. Irritability. Note: Along with irritability, a host of “anger” problems can develop during menopause. Just as a perimenopausal woman can find herself suddenly crying for no apparent reason or provocation, so can she find herself reacting to given situations in an angrier manner than she normally does. This anger can sometimes feel like “rage.”

Again, this is hormone-induced, but for some women, the anger can become inappropriate and a woman can feel like she’s out of control. There’s nothing wrong with seeking counselling to discuss these issues with a mental health professional. This is a challenging time of life and some objective outside help can be tremendously useful in helping a woman cope with all the emotions she’s feeling. Remember, menopause isn’t simply physical changes, but emotional and spiritual changes as well. There’s an excellent forum on the Power Surge Message Board that deals with the issues of Anger / Mood Swings / Rage.

4. Mood swings, sudden tears. Note: Mood swings can include anything from mood shifts (happy one moment, depressed the next) to sudden bouts of crying when nothing overt has occurred to cause the crying. Mood swings can and have been misdiagnosed as bipolar disorder because one can feel such extremes of emotions due to hormone imbalance. Anxiety, depression, panic attacks and even feelings of agoraphobia aren’t uncommon during menopause. The panic attacks often can develop with the onset of hot flashes. For some women, hot flashes can be severe and quite frightening.

5. Trouble sleeping through the night (with or without night sweats). Note: This can develop into insomnia or just waking at 2 in the morning for an hour. Relaxation and breathing exercises can be useful at this time — many women may log onto the Power Surge message boards and are surprised to find so many other women there in the middle of the night. More help on the Insomnia, Sleep Disorders Forum

6. Irregular periods: shorter, lighter or heavier periods, flooding, and phantom periods. Note: A phantom period is when you experience all the symptoms you’re accustomed to having before you menstruate — but… no period comes. This is a common experience during perimenopause before a woman’s period actually stops.

7. Loss of libido (sex drive). Note: Not every woman loses her libido entirely during perimenopause, although some may temporarily. Many women simply have a decreased interest in sex – often it’s simply because they generally don’t feel well and sex is the last thing on their mind! Also, bear in mind that there are many medications that can affect one’s libido, including the anti-depressants some women take to cope with the depression and anxiety associated with menopause to anti-hypertensives.

8. Dry vagina (results in painful intercourse) Note: Click here for an excellent article about vaginal dryness, sexuality and midlife relationships. Recommended: Sexual Issues/Libido Forum

9. Crashing fatigue. Note: I’ve never been able to determine if the “fatigue” associated with perimenopause is a symptom in and of itself, or if it’s a side effect of the cumulative symptoms and general exhaustion (from them) many women experience. Take all the symptoms and “dump” them on one person — is it any wonder perimenopausal women are so fatigued? If you can, try to find time to grab a nap.

One of the things that helped my fatigue, and it’s all chronicled in my personal odyssey to find remedies, is the use of considerable amounts of soy isoflavones and protein, which I found in R Soy. I can’t say that it specifically targetted and relieved the crashing fatigue, but it helped so many other symptoms and gave me a burst of energy, that I feel comfortable in attributing the fatigue relief to R. There are various vitamins, such as those in the “B” family, that can help with fatigue as well. Also, increased amounts of vitamin C. The Recommendations page lists numerous vita-nutrients that can be useful in treating fatigue and other symptoms associated with perimenopause.

10. Anxiety, feeling ill at ease. Note: One of the biggest complaints during menopause. Read the Anxiety/Stress Forum

11. Feelings of dread, apprehension, and doom (includes thoughts of death, picturing one’s own death). Note: It’s possible that this can be a manifestation of depression associated with menopause, or possibly feelings that come from going through daily discomfort through a difficult menopause transition that can last anywhere from 3-12 years.

A woman living under these circumstances can feel totally overwhelmed and frightened by the physical, psychological and spiritual changes. When there seems to be no reprieve from the suffering, for some it can leave them feeling drained wondering when and IF they’ll ever feel well again. It isn’t unusual for women at this time of life to have thoughts about dying. One phase of their life is coming to a close (not soon enough for many). There may be apprehension and fear about moving on to the next phase of life and wondering whether things will get better or worse. Helpful: The Panic Attacks / Disorder / Fear / Apprehension Forum

12. Difficulty concentrating, disorientation, & mental confusion. Note: Forgetfulness during perimenopause is often referred to lightly and humorously as “brain fog” but it’s not always funny. Note: An excellent article, Menopause And The Mind. Also, visit the Memory Loss, Foggy Thinking, Forgetfulness, Verbal Slips Forum

13. Disturbing memory lapses. Note: See #12

14. Incontinence — especially upon sneezing, laughing: urge incontinence (reflects a general loss of smooth muscle tone).

15. Itchy, crawly skin (feeling of ants crawling under the skin, not just dry, itchy skin Note: the feeling of ants crawling on your skin is called “formication”) Visit the Your Skin: Dryness, Itching, Vaginal Dryness, Disorders, Discomfort Forum

16. Aching, sore joints, muscles and tendons. (may include such problems as carpal tunnel syndrome). Note: Osteoarthritis can develop during perimenopause – and those with existing arthritic and/or rheumatic pain may find it’s exacerbated during the menopausal transition. See the Joints Aches and Pains/Arthritis Forum

17. Increased tension in muscles.

18. Breast tenderness. Note: Breast swelling, soreness, pain.

19. Headache change: increase or decrease. Note Many women develop migraine headaches during perimenopause. However, if one doesn’t have a history of migraine headeaches, they’re generally a short-lived experience of perimenopause. Also see the Headaches, Migraine Forum

20. Gastrointestinal distress, indigestion, flatulence, gas pain, nausea. Note: For nausea, try some ginger or, as I use, boiling hot water with a few teaspoons of lemon or lemon juice concentrate in it. Many women also develop acid reflux (Gerd). For some, it can be an uncomfortable feeling of severe burning sensations in the throat. If it persists, see your health care practitioner.

21. Sudden bouts of bloat. Note: Bloating, water retention are common complaints during perimenopause. Also, Acid reflux and heartburn are very common during perimenopause. Treat them as you would if you weren’t going through menopause.

22. Depression (has a quality from other depression, the inability to cope is overwhelming, there is a feeling of a loss of self. Natural hormone therapy, ameliorates the depression dramatically). Note: There are various natural methods of treating depression. Read Power Surge’s Menopause Survival Tips.

Also, many women using progestins or progesterone supplementation experience “depression” as a side effect. Power Surge recommends only naturally compounded, bio-identical hormones. Naturally compounded estrogen and progesterone supplementation doses can be individually adjusted to suit each woman’s needs. So, if a woman is experiencing depression from progesterone, the level of progesterone supplementation can be reduced until the compounding pharmacist comes up with the right blend. The combination of estrogen and progesterone is important in achieving the desired results. Other remedies, such as St. John’s Wort can be very effective in alleviating the depression associated with menopause.

My personal experience was that my perimenopause-related depression was eliminated when I started using R Soy Protein. R is excellent for mood swings, but I was astonished by the impact it had on the hormone-related “lows” I experienced before using it. Also recommended, The Depression Forum

23. Exacerbation of any existing conditions. Note: Often, conditions women had prior to entering perimenopause become
exaggerated (worse) during the menopause transition.

24. Increase in allergies. Note: Many women who suffer from allergies develop worse allergies during the menopausal years. Many women who’ve never had allergy or respiratory problems may develop them for the first time. Many people don’t realize that histamine levels are affected by hormone levels. Women can develop wheezing, coughing and a host of respiratory problems. This generally disappears as the hormones level out once a woman becomes menopausal.

25. Weight gain. (is often around the waist and thighs, resulting in “the disappearing waistline” and changes in body shape.) A good read, Weight Gain and Fitness Issues

26. Hair loss or thinning, head or whole body, increase in facial hair. Note: There is often a loss of pubic hair during menopause. Many women are more comfortable simply shaving their pubic area instead of having patches of hair.

27. Dizziness, light-headedness, episodes of loss of balance. Note: Although common complaints during menopause, I always recommend anyone suffering from dizziness, dysequilibrium have her blood pressure checked just to be on the safe side. However, women can experience these symptoms during perimenopause without having hypertension.

28. Changes in body odor. Note: I wouldn’t be too concerned about this one. It can happen, but in 13 years of running Power Surge, I’ve heard of relatively few cases of developing body odor during menopause.

29. Electric shock sensation under the skin & in the head (“take the feeling of a rubber band snapping against the skin, multiply it (exponentially, sometimes) radiate it & put it in the layer of tissues between skin & muscle & sometimes a precursor to a hot flash.”) Note: Those buzzing sensations, as though you’ve put your finger into a live electrical socket, can be frightening. They’re all part of the hormones, nerve endings and electrical waves running through our bodies when our hormones are constantly fluctuating. Many women experience this during perimenopause, but it eventually passes.

30. Tingling in the extremities (can also be a symptom of B-12 deficiency, diabetes, or from an alteration in the flexibility of blood vessels n the extremities.)

31. Gum problems, increased bleeding.

32. Burning tongue

33. Osteoporosis (after several years)

34. Brittle fingernails, which peel & break easily.

Some additional signs from Dearest:

  • Internal shaking / tremor-like feelings. Read the Internal Shaking Forum
  • Acne and other skin eruptions
  • Itching wildly and erratic rashes
  • Shoulder pain / joints / arthritis development or flare up in
    preexisting conditions
  • “Heart pain” – a feeling of pain in the area of the
    heart (if persistent, get checked by your health care practitioner)
  • Acid reflux / heartburn / difficulty digesting certain foods

Some of the 34 signs may also be symptoms of one of the following:

  • Hypothyroidism
  • Diabetes
  • Depression with another etiology
  • Other medical conditions (see The Educate Your Body Library)

If you have reason to believe you may have one of these conditions, see your healthcare practitioner for treatment.

Dearest

Note: Remember that although these may be common complaints during menopause, they might also indicate some other health problem. Be sure to consult with your personal health care practitioner before attributing these symptoms to menopause.